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October 26, 2020 2 min read

What is L-Isoleucine?

L-Isoleucine is an EAA and BCAA

L-Isoleucine, simply referred to as Isoleucine from here on out, is an Essential Amino Acid (EAA) that is part of only three EAAs that form the subgroup called Branched-chain Amino Acids (BCAAs).

BCAAs are different from the other EAAs because they are more quickly available to be used by your body due to them being metabolized in your muscles and not in your liver.[1]

"Isoleucine Builds Muscle and Burns Fat?"

Muscle Building

BCAAs, generally speaking, increase Muscle Protein Synthesis that may help you Build More Muscle and Recover Better from your workouts.[2] However, each BCAA is different and each one has unique properties that make it special.  

Fat Burning

According to recent clinical studies, Isoleucine appears to play a major role in the Fat Burning benefits of BCAAs.

Scientists studying Amino Acids recently discovered that mice given Isoleucine while eating a high fat diet gained significantly less fat than mice not given Isoleucine.[3]

Burn More Fat and Store Less Fat!

Isoleucine's Fat Burning properties are thought to be due to its ability to both activate special receptors that Increase Fat Burning while decreasing the activity of genes that normally increase fat storage.  

No Wonder BCAA Supplements are so Popular!

Choosing the Correct Ratio

"While Leucine is the Star Amino when it comes to Muscle Building, Isoleucine is Burns Hot when it comes to Fat Loss." 

While Leucine plays the largest role in Muscle Protein Synthesis, it should be taken with the other BCAAs, including Isoleucine, to not only Maximize Muscle Growth, but to also Increase the Lean Mass Support and Fat Burning Properties offered by a Complete, High Quality BCAA Supplement.

Learn More About Action Nutrition's BCAA Loaded HERE!

Coveted 12:1:1 BCAA Ratio

5 Grams of Leucine per Serving

500 Milligrams Coconut Water Powder for Hydrations


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    1. Layman, D. K. (2003). The role of leucine in weight loss diets and glucose homeostasis. The Journal of Nutrition, 133(1), 261S-267S.
    2. Blomstrand, E., Hassmén, P., Ek, S., Ekblom, B., & Newsholme, E. A. (1997). Influence of ingesting a solution of branched‐chain amino acids on 
    3. Nishimura, J., et al. "Isoleucine Prevents the Accumulation of Tissue Triglycerides and Upregulates the Expression of PPAR{alpha} and Uncoupling Protein in Diet-Induced Obese Mice." J. Nutr., March 2010, in press.